Table 2.
SNPs in the VEGFR2 gene associated with glioblastoma prognosis in cases collected between 2000 and 2004 as part of the Interphone study
| rs number | Gene | Region | Major allele | Genotype | No. (%) | HR (95% CI) | P value | Median survival time |
|---|---|---|---|---|---|---|---|---|
| rs2071559 | VEGFR2 | Promotor | C | CC | 39 (26.0) | 1.0 | 14.0 | |
| CT | 72 (48.0) | 1.68 (1.06–2.67) | 0.028 | 12.1 | ||||
| TT | 39 (26.0) | 0.90 (0.52–1.56) | 0.702 | 13.9 | ||||
| rs12502008 | VEGFR2 | Intron 1 | G | GG | 56 (37.1) | 1.0 | 12.5 | |
| GT | 77 (51.0) | 1.09 (0.74–1.62) | 0.659 | 12.8 | ||||
| TT | 18 (11.9) | 0.45 (0.21–0.95) | 0.036 | 14.7 |
All hazard ratios (HR) are adjusted for country, sex, age, surgery, radio- and chemotherapy