Table 5.

Frequencies of the alleles and predicted phenotypes for the TNF-α -308 polymorphism according to severity criteria.

	Allele			TNF-α predicted phenotype
Severity Criteria	An (%)	Gn (%)	p-value	High producern (%)	Low producern (%)	p-value
Immunosuppressive treatment	10 (37.0)	60 (38.7)	NS	8 (30.1)	27 (38.6)	NS
Steroid treatment	19 (70.4)	101 (65.2)	NS	15 (71.4)	45 (64.3)	NS
Fistula surgery	8 (29.6)	24 (15.5)	NS	5 (23.8)	11 (15.7)	NS
Colectomy	10 (37.0)	30 (19.4)	0.04	9 (42.9)	11 (15.7)	0.02
Small bowel resection	5 (18.5)	13 (8.4)	0.03*	5 (31.3)	4 (5.7)	NS
Hospitalization in the last year †	8 (29.6)	48 (31.4)	NS	6 (28.6)	22 (31.9)	N

^†90 patients, with 27 A alleles, 153 G alleles, 21 high producers and 69 low producers.

^*Fisher's exact test. NS, not statistically significant.