Table 3.

HRs for fatal/nonfatal CHD and quartiles or tertiles of lipid measures at Cox proportional hazards regression in 18,673 patients with type 2 diabetes followed for 5 years

Lipid measures	HR (95% CI)*	P
Quartiles
Non-HDL:HDL
Quartile 1 (<2.27)	1.0
Quartile 2 (2.27–2.99)	1.31 (1.08–1.58)	0.007
Quartile 3 (3.0–3.90)	1.71 (1.42–2.05)	<0.001
Quartile 4 (≥3.91)	1.94 (1.61–2.32)	<0.001
Non-HDL cholesterol (mmol/L)
Quartile 1 (<3.10)	1.0
Quartile 2 (3.10–3.69)	1.20 (1.01–1.43)	0.04
Quartile 3 (3.70–4.34)	1.37 (1.16–1.63)	<0.001
Quartile 4 (≥4.35)	1.72 (1.46–2.03)	<0.001
LDL cholesterol (mmol/L)
Quartile 1 (<2.36)	1.0
Quartile 2 (2.36–2.92)	1.12 (0.94–1.32)	0.2
Quartile 3 (2.93–3.53)	1.14 (0.97–1.35)	0.1
Quartile 4 (≥3.54)	1.51 (1.28–1.78)	<0.001
TG:HDL
Quartile 1 (<0.80)	1.0
Quartile 2 (0.80–1.26)	1.34 (1.11–1.61)	0.003
Quartile 3 (1.27–1.95)	1.54 (1.28–1.85)	<0.001
Quartile 4 (≥1.96)	1.61 (1.34–1.95)	<0.001
Tertiles
Non-HDL:HDL
Tertile 3 (ref.)†	1.0
Tertile 1 (<2.5)	0.62 (0.50–0.77)	<0.001
Decile 1 (<1.7)	0.52 (0.38–0.71)	<0.001
Non-HDL cholesterol (mmol/L)
Tertile 3 (ref.)†	1.0
Tertile 1 (<3.3)	0.65 (0.53–0.80)	<0.001
Decile 1 (<2.6)	0.62 (0.47–0.81)	<0.001
LDL cholesterol (mmol/L)
Tertile 3 (ref.)†	1.0
Tertile 1 (2.5)	0.70 (0.58–0.85)	<0.001
Decile 1 (≤1.8)	0.66 (0.51–0.86)	<0.001
TG:HDL
Tertile 3 (ref.)†	1.0
Tertile 1 (<0.9)	0.66 (0.53–0.82)	<0.001
Decile 1 (<0.5)	0.55 (0.39–0.78)	<0.001

*HRs adjusted for age, sex, diabetes duration, type of hypoglycemic treatment, HbA_1c, systolic blood pressure, smoking, BMI, albuminuria >20 µg/min, and a history of CVD.

†Reference group: tertile 3 of non-HDL:HDL (≥3.6), non-HDL cholesterol (≥4.1 mmol/L), LDL cholesterol (≥3.3 mmol/L), and TG:HDL (≥1.7). Tertile 1 and decile 1 of a lipid measure were compared with this reference group.