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. 2011 Aug 20;60(9):2206–2215. doi: 10.2337/db11-0004

FIG. 6.

FIG. 6.

NOD1-mediated hepatocyte inflammation and insulin resistance. Quantification of (A) CXCL1 secretion and (B) nitrite from primary hepatocytes of WT and NOD1−/− mice after exposure to NOD1 ligands (5 μg/mL of FK565 or 100 ng/mL of c12-iEDAP) for 18 h. Representative immunoblots of phospho-Akt (pAkt) and total Akt from primary hepatocytes of (C) WT and (D) NOD1−/− mice. The dotted line indicates splicing of the gel to remove unrelated samples. Densitometric quantification of pAkt/Akt in (E) WT and (F) NOD1−/− primary hepatocytes under basal and insulin-stimulated (100 nmol/L for 2 min) conditions. *P < 0.05, compared with vehicle control (CON). Data are means ± SE, n ≥3 per group. (A high-quality color representation of this figure is available in the online issue.)