Table 1.
Allele and Genotype frequencies for the MDR1 and CYP3A observed in Ghanaian population (%, 95% CI in parenthesis)
| MDR1 3435C > T | CYP3A4*1B | CYP3A5*3 | CYP3A5*6 | |
|---|---|---|---|---|
| Total no genotyped | 194 | 203 | 200 | 194 |
| Major allele | 153 | 15 | 141 | 141 |
| homozygous | (78.9, 73.1 - 84.6) | (7.4, 3.79 - 11.0) | (70.5, 64.1 - 76.8) | (72.7, 66.4 - 79.0) |
| Heterozygous | 38 | 86 | 58 | 51 |
| (19.6, 14 - 25.2) | (42.4, 35.6 - 49.2) | (29, 22.7 - 35.3) | (26.3, 20.1 - 32.5) | |
| Minor allele | 3 | 102 | 1 | 2 |
| homozygous | (1.6, -0.19 - 3.3) | (50.3, 43.4 - 57.1) | (0.05, -0.5 - 1.5) | (1.03, -0.4 - 2.5) |
| Major allele | 89 | 28 | 85 | 86 |
| frequency | (84.6 - 93.4) | (21.8 - 34.2) | (80.1 - 90.0) | (81.1 - 90.9) |
| Minor allele | 11 | 72 | 15 | 14 |
| frequency | (6.6 - 15.4) | (65.8 - 78.2) | (10.1 - 20.0) | (9.1 - 18.9) |
CI, Confidence interval. MDR1 (1236C > T), MDR1 (2677G > A), MDR1 (2677G > T), CYP3A4*3 variant alleles were not detected in this study population