Table 2.
Allele and Genotype frequencies for the MDR1 and CYP3A observed in IVM treated subjects (%, 95% CI in parenthesis)
| MDR1 3435C > T | CYP3A4*1B | CYP3A5*3 | CYP3A5*6 | |||||
|---|---|---|---|---|---|---|---|---|
| RES | SOR | RES | SOR | RES | SOR | RES | SOR | |
| Total no genotyped | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 |
| Major allele | 16 | 12 | 3 | 1 | 9 | 13 | 18 | 17 |
| homozygous | (76, 57.3 - 94.3) | (57, 35.9 - 78.2) | (14, -0.8 - 28.8) | (5, -4.3 - 14.3) | (43, 21.8 - 64.2) | (62, 41.2 - 82.8) | (86, 71.2 - 100) | (81, 62.4 - 97.8) |
| Heterozygous | 5 | 9 | 11 | 11 | 11 | 7 | 3 | 3 |
| (24, 5.7 - 42.3) | (43, 21.8 - 64.2) | (53, 31.7 - 74.4) | (52, 3.6 - 73.4) | (52, 30.6 - 73.4) | (33, 12.9 - 53.1) | (14, -0.8 - 28.8) | (14, -0.8 - 28.8) | |
| Minor allele | 0 | 0 | 7 | 9 | 1 | 1 | 0 | 1 |
| homozygous | (33, 12.9 - 53.1) | (43, 21.8 - 64.2) | (5, -4.3 - 14.3) | (5, -4.3 - 14.3) | (5, -4.3 - 14.3) | |||
| Major allele | 18 | 17 | 8 | 14 | 14 | 17 | 20 | 18 |
| frequency | (88, 74.1 - 101) | (79, 61.6 - 96.4) | (40, 19.1 - 61) | (69, 49.2 - 88.8) | (69, 49.2 - 88.8) | (79, 61.6 - 96.4) | (93, 82.1 - 103 | (88, 74.1 - 101) |
| Minor allele | 3 | 4 | 13 | 7 | 7 | 4 | 1 | 3 |
| frequency | (12, -1.9 - 25.9) | (21, 3.6 - 38.4) | (60, 30.1 - 81) | (31, 11.2 - 50.8) | (31, 11.2 - 50.8) | (21, 3.6 - 38.4) | (7, -3.9 - 17.9) | (12, -1.9 - 25.9) |
CI, Confidence interval. MDR1 (1236C > T), MDR1 (2677G > A), MDR1 (2677G > T), CYP3A4*3 variant alleles were not detected in this study population