Table 2.
Plasma parameters in 3 month-old WNIN/Ob lean and obese rats.
| Lean (n = 6) | Obese (n = 6) | |
|---|---|---|
| Corticosterone (ng/ml) | 213 ± 34 | 433 ± 50* |
| Insulin (μU/ml) | 7.0 ± 3.6 | 206 ± 23* |
| Triglycerides (mg/dl) | 46.5 ± 3.0 | 212 ± 29* |
| Glucose (mg/dl) | 80.0 ± 2.0 | 86.0 ± 4.7 |
| HOMA-IR | 1.4 ± 0.8 | 52.5 ± 7.0* |
| Glucose AUC (mmol/l) | 304 ± 13 | 472 ± 31* |
| Insulin AUC (μU/ml) | 5.1 ± 1.2 | 32 ± 2.8* |
| Glucose AUC/Insulin AUC (× 1000) | 74 ± 14 | 15 ± 1.4* |
| Leptin (ng/ml) | 1.0 ± 0.1 | 14.2 ± 1.8* |
| TNF-α (pg/ml) | 3.0 ± 1.6 | Nd |
| IL-6 (ng/ml) | 191 ± 62 | 57.5 ± 35 |
| MCP-1 (μg/ml) | 0.3 ± 0.1 | 2.5 ± 2.3 |
Values are mean± S.E of 6 rats. Values with * mark are significant at P < 0.05 level (by student's t test). Comparisons were made between lean and obese phenotypes. Nd, non-detectable.