Table 6.
Urine Osmolality for the Control group with daily PA, SRWC, and PRAL subgroup analyses (Mean (SE)).
| Control Condition | Pre-Treatment Period | Treatment Period | Post-Treatment Period | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M1 | M2 | M3 | M4 | M5 | M6 | M7 | M8 | M9 | M10 | M11 | M12 | |
| All Subjects | 495 | 424 | 466 | 450 | 439 | 470 | 419 | 448 | 430 | 480 | 488 | 425 |
| (n = 19) | (52) | (42) | (54) | (51) | (55) | (42) | (41) | (42) | (50) | (54) | (47) | (43) |
|
Low PA (n = 9) |
509 (64) |
478 (67) |
483 (69) |
512 (76) |
515 (70) |
418 (76) |
461 (80) |
465 (78) |
445 (81) |
493 (77) |
468 (79) |
479 (50) |
|
High PA (n = 10) |
483 (66) |
375 (56) |
451 (57) |
394 (40) |
370 (41) |
516 (60) |
382 (36) |
370 (35) |
416 (50) |
461 (68) |
506 (57) |
467 (68) |
|
Low SRWC (n = 9) |
538 (66) |
499 (55) |
538 (69) |
502 (60) |
469 (67) |
506 (71) |
426 (37) |
430 (36) |
470 (67) |
515 (61) |
483 (54) |
433 (52) |
|
High SRWC (n = 10) |
456 (69) |
356 (56) |
402 (72) |
403 (69) |
412 (70) |
437 (50) |
413 (72) |
410 (70) |
394 (58) |
446 (69) |
493 (77) |
419 (69) |
|
Low PRAL (n = 9) |
466 (64) |
444 (72) |
495 (69) |
452 (75) |
457 (76) |
455 (77) |
398 (44) |
410 (44) |
441 780) |
493 (74) |
468 (63) |
380 (59) |
|
High PRAL (n = 10) |
521 (66) |
406 (49) |
440 (68) |
448 (72) |
423 (72) |
480 (60) |
438 (69) |
435 (60) |
442 (80) |
466 (69) |
506 (71) |
466 (62) |
Note: There were a total of twelve 24-hour urine collections labeled in the table as M1-M12, respectively. Mean osmolality values were compared directly with respective mean Pre-Treatment reference value which were averages of all M1-M3 values within the condition and subject group being evaluated. These Pre-Treatment reference values were as follows: 462 (all Control subjects), 490 (low PA), 436 (high PA), 525 (low SRWC), 405 (high SRWC), 468 (low PRAL), and 456 mOsm/kg (high PRAL). There were no significant differences detected for any of the evaluations.