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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Pain. 2011 Aug 1;152(8):1832–1837. doi: 10.1016/j.pain.2011.03.034

Figure 2.

Figure 2

The effect of the anti-oxidants N-acetyl-L-cysteine (NAC) and glutathione on NGF-hyperalgesia. A. Various doses of both NAC and glutathione were administered thirty minutes after NGF in order to determine the doses to be used for testing. For NAC the highest dose (10 μg) was chosen because it attenuated NGF hyperalgesia significantly more than any of the lower doses. For glutathione the effect of the 10 μg dose was not significantly greater than that of the 5 μg dose, therefore the 5 μg dose was chosen for testing. B. NAC (10 μg) attenuated NGF hyperalgesia detectable at 1 hour and lasting up to 24 hours. C. Glutathione (5 μg) attenuated NGF hyperalgesia detectable at 30 minutes, but the effect was no longer significant by 24 hours. N = 6 for all groups. Data are plotted as mean ± SEM. Significant difference between the groups are indicated by asterisks (*) plotted above the time points where they apply. Abbreviation: PWT = paw-withdrawal threshold.