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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Pain. 2011 Aug 1;152(8):1832–1837. doi: 10.1016/j.pain.2011.03.034

Figure 3.

Figure 3

Effect of cytoskeletal inhibitors on NGF hyperalgesia. A. Latrunculin B, an actin disruptor had no significant effect on NGF hyperalgesia and any time point. B. Nocodazole, a microtubule disruptor, attenuated hyperalgesia up to 24 hours after NGF administration of hyperalgesic agent (n=6). C. Both Latrunculin B and nocodazole significantly attenuated epinephrine-induced hyperalgesia as demonstrated previously (Dina et al., 2003) (shown here as a positive control). Note that this experiment was not carried out to 24 hours because epinephrine-induced hyperalgesia lasts less than three hours. N = 6 for all groups. Data are plotted as mean ± SEM. Significant difference between the groups are indicated by asterisks (*) plotted above the time points where they apply. Abbreviations: PWT = paw-withdrawal threshold; EPI = epinephrine.