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. Author manuscript; available in PMC: 2011 Aug 25.
Published in final edited form as: J Am Chem Soc. 2006 Jan 25;128(3):732–733. doi: 10.1021/ja057237l

Scheme 2.

Scheme 2

Asymmetric Synthesis of β-Lactam, Aziridine and α-Methylcysteine Derivatives a

(a) Raney Ni, H2 (1atm); (b) i-PrMgCl, 38% y. over 2 steps; (c) TfN3, CuSO4(cat.), for 6c, 84 % y. over 2 steps; for 6j, 63% y. over 2 steps; (d) PPh3, CH3CN, for 7c, 80% y.; for 7j, 71% y.; (e) BF3. Et2O, p-Methoxybenzyl mercaptan, 56% y.

aSee Supporting Information for details.