Table 5.

Comparison of K₁’s and DVs for 3 (n=8), 6 (n=5) and 10 (n=4) in the baboon brain using baseline studies represented as the mean ± standard deviation. Values are also shown for [¹⁸F] FP-TZTP in rhesus monkey brain for comparison [10].

Tracer	cerebellum	striatum	thalamus	cingulate	parietal	occipital	temporal
K1’s
11C-FP-TZTP	1.03 ±0.37	0.97 ±0.40	0.92 ±0.56	0.68 ±0.27	0.63 ±0.29	0.92±0.36	0.66 ±0.25
11C-P-TZTP	0.78 ±0.27	0.67 ±0.15	0.61 ±0.16	0.50 ±0.13	0.44 ±0.11	0.56 ±0.10	0.50 ±0.12
11C-F3P- TZTP	1.49 ±0.54	1.49 ±0.57	1.24 ±0.50	0.94 ±0.34	0.79 ±0.28	1.10 ±0.43	0.96 ±0.29
[18F] FP-TZTP	0.62 ±0.27	0.52 ±0.24	0.51 ±0.23	0.48 ±0.23	0.40 ±0.21	0.38 ±0.17	0.47 ±0.20
DV’s
11C-FP-TZTP	13.9 ±2.6	22.0 ±3.5	17.6 ±3.9	19.0 ±3.7	19.7 ±4.3	17.0 ±5.0	20.3 ±4.4
11C-P-TZTP	17.8 ±1. 7	25.0 ±3.3	20.0 ±1.9	23.2 ±2.4	22.6 ±2. 6	20.8 ±3.1	24.3 ±3.0
11C-F3P- TZTP	139.6 ±32.7	150.0 ±55.9	174.3 ±71.1	176.6 ±65.8	160.7 ±69.8	143.1 ±56.2	175.1 ±68.0
[18F] FP-TZTP	15.7 ±3.8	25.6 ±5.8	23.2 ±6.1	26.5 ±7.5	25.5 ±6.9	21.7 ±6.0	24.4 ±5.3

^aFor ¹¹C-FP-TZTP with the exception of the occipital, the cerebellum has a significantly smaller DV (p < 0.05) than other brain regions.

^bFor ¹¹C-P-TZTP with the exception of the occipital and thalamus, the cerebellum has a significantly smaller DV (p < 0.05) than other brain regions.

^cFor ¹¹C-F₃P-TZTP there is no significant difference in DV (p < 0.05) for all brain regions studied.

^dWith the exception of the cerebellum and the cingulate DVs for a given brain region is similar for ¹¹C-FP-TZTP and ¹¹C-P-TZTP.

^e11C-F₃P-TZTP has significantly larger DVs (p < 0.05) in all brain regions as compared to ¹¹C-FP-TZTP and ¹¹C-P-TZTP.