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. 2011 Aug 8;108(34):14222–14227. doi: 10.1073/pnas.1111786108

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Fig. 4. — CIA is significantly suppressed in Lck-Cre Ahr^flox/flox mice. Ahr^flox/flox and Lck-Cre Ahr^flox/flox mice were immunized with collagen. Mice were assessed for the clinical arthritis score (A), disease incidence (B), and maximum CIA score (C) until day 60. Data are presented as the mean clinical and maximum scores ± SEM (Ahr^flox/flox, n = 12; Lck-Cre Ahr^flox/flox, n = 11). Fourteen days after the second immunization, sera were collected and levels of the proinflammatory cytokines IL-1β (D) and IL-6 (E) were measured using specific ELISAs (Ahr^flox/flox, n = 6; Lck-Cre Ahr^flox/flox, n = 6). (F) CD4⁺ T cells selected from inguinal lymph node cells by MACS obtained from mice 14 d after the second immunization were counted after IFN-γ, IL-17, or Foxp3 were intracellularly stained (Ahr^flox/flox, n = 7; Lck-Cre Ahr^flox/flox, n = 7; *P < 0.05; **P < 0.01).