Fig. 3.

Leucine incorporation at the SerRS dimer interface induces subtle structural changes. (A) SerRS_Ser197 dimer interface, with residues involved in polar intermonomer interactions (Asn189 and Asn193) shown as sticks, and the CUG-encoded serine in cyan. Part of the mostly water (red spheres) mediated hydrogen bond network centered on Ser197 is shown as dashed black lines. (B) Superposition of the 3D structures of C. albicans SerRS natural isoforms. SerRS_Leu197 colored in mauve and SerRS_Ser197 colored as in Fig. 2A. The shifting residues in the immediate vicinity of residue 197 are represented as sticks.