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Comparison of 125I-p5 tissue retention with amyloid load as evidenced in Congo red-stained tissue sections. Tissue biodistribution of 125I-p5 in the liver (A) and spleen (B) of AA mice at 2 h pi correlated linearly with the qualitative measure of amyloid burden (0–4+ scale) assessed in Congo red-stained tissue sections. The correlation was significant based on Spearman correlation coefficients and P values for the liver (0.95 and 9 × 10−13) and spleen (0.84 and 1 × 10−7).
