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. 2008 Mar 27;2:275–287. doi: 10.4137/cmo.s615

Figure 2. Two distinct populations of B cells in MM patients.

Figure 2

Respresentative staining of PBMC from a healthy donor and an MM patient in two color immunofluorescence with Leu12-PE and FMC63-FITC, showing two distinct populations of B cells in MM patients (CD19+ Leu12− and CD19+ Leu12+) but only one in healthy donors (CD19+Leu12+). Previous work has shown that the Leu12− populations detected by B4 and FMC63 are B cells and express clonotypic transcripts (Pilarski, Giannakopoulos, Szczepek, Masellis, Mant, and Belch 2000a; Pilarski, Szczepek, and Belch 1997; Szczepek, Seeberger, Wizniak, Mant, Belch, and Pilarski 1998; Szczepek, Bergsagel, Axelsson, Brown, Belch, and Pilarski 1997).