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. 2008 Mar 27;2:275–287. doi: 10.4137/cmo.s615

Figure 7. A proportion of Leu12+ MM B cells are clonotypic.

Figure 7

FMC63+Leu12− (monocytoid gates) and FMC63+Leu12+ (lymphocyte gates) B cells were sorted and analyzed for clonotypic IgH VDJ transcripts using in situ RT-PCR. Leu12− monocytoid B cells were sorted from PBMC of 12 MM patients. Leu12+ lymphocyic B cells were sorted from PBMC of 15 MM patients. Leu12 negative B cells included significantly more clonotypic B cells than did Leu12+ B cells (p = .003). One of the patients analyzed for clonotypic Leu12+ B cells was in a terminal stage of disease.