Table 2.
The sensitivity/specificity and PPV/NPV of each tumor marker for hepatocellular carcinoma are shown. PPV: positive predictive value, NPV: negative predictive value (A). Statistical significance in each tumor marker during hepatocarcinogenesis is shown (B).
| A.
| ||||
|---|---|---|---|---|
| Sensitivity | Specificity | p value | PPV/NPV | |
| AFP | 0.693 | 0.600 | 0.002 | 0.812/0.389 |
| AFP-L3 | 0.563 | 0.925 | 0.304 | 0.778/0.277 |
| DCP | 0.815 | 0.635 | <0.001 | 0.852/0.405 |
| AFP mRNA | 0.716 | 0.675 | <0.001 | 0.695/0.741 |
| hTERT mRNA | 0.882 | 0.700 | <0.001 | 0.862/0.870 |
| B.
| ||||
|---|---|---|---|---|
| Tumor marker | CH/LC → HCC
|
LC → HCC
|
||
| (n = 40) | (n = 64) | (n = 20) | (n = 64) | |
| AFP level | 0.376 | 0.532 | ||
| AFP-L3 | 0.144 | 0.228 | ||
| DCP | 0.317 | 0.479 | ||
| AFP mRNA | 0.001 | 0.001 | ||
| hTERT mRNA | <0.001 | <0.001 | ||