Table 3.
Statistical analysis of the comparison between pulmonary tumor markers and clinical parameters.
| Clinical parameters | No. of patients | One way ANOVA Bonferroni
|
||||
|---|---|---|---|---|---|---|
| hTERT mRNA
|
EGFR mRNA
|
CEA
|
SCC
|
CYFRA
|
||
| p | p | p | p | p | ||
| Age mean:63 years old (range 22 to 90) | NS | NS | NS | NS | NS | |
| Gender | ||||||
| M | 72(15) | NS | NS | NS | NS | NS |
| F | 44(12) | |||||
| Smoking | ||||||
| Y | 48 | 0.029 | NS | 0.031 | NS | NS |
| N | 41 | |||||
| Number of tumors | ||||||
| 1 | 48 | 0.003 | 0.047 | NS | 0.016 | 0.017 |
| 2 | 13 | |||||
| >3 | 26 | |||||
| unknown | 2 | |||||
| Numbers of occupied segment | 0.029 | NS | 0.031 | NS | NS | |
| 1 | 50 | |||||
| 2 | 16 | |||||
| >3 | 8 | |||||
| unknown | 15 | |||||
| Diagnosis | ||||||
| ADC | 60 | NS | NS | NS | NS | NS |
| SCC | 15 | |||||
| others | 6 | |||||
| (benign | 8) | |||||
| Size of tumor | ||||||
| <2 cm | 22 | 0.002 | 0.043 | NS | 0.015 | 0.019 |
| 2~3 cm | 28 | |||||
| >3 cm | 38 | |||||
| unknown | 1 | |||||
| Metastasis | ||||||
| Y | 38 | 0.004 | NS | NS | 0.044 | 0.045 |
| N | 49 | |||||
| unknown | 2 | |||||
| Recurrence | ||||||
| Y | 32 | 0.013 | 0.037 | NS | NS | 0.009 |
| N | 50 | |||||
| unknown | 7 | |||||
| Staging (K-W test) | ||||||
| I A, II B | 12, 9 | NS | 0.032 | NS | NS | NS |
| II A, II B | 1, 7 | |||||
| III A, III B | 17, 1 | |||||
| IV | 5 | |||||
hTERT mRNA correlated with smoke, tumor size, number of tumors, metastasis, and recurrence, independently.
Abbreviations: K-W test, Kruskal-Wallis test: ADC, Adenocarcinoma: SCC, Squamous cell carcinoma related antigen: CEA, Carcinoembryonic antigen: CYFRA, Cytokeratin 21-1 fragment: NS, not significant. The numbers in parenthesis in the column of Gender indicate the number of healthy individuals.