Table 4.
Sensitivity/specificity of each tumor marker for lung cancer.
| Sensitivity | Specificity | p value | PPV/NPV | Cut-off point | |
|---|---|---|---|---|---|
| hTERT mRNA | 71.8 | 72.5 | 0.006 | 77.5/66.7 | 3.76(10x copy) |
| EGFR mRNA | 60.8 | 62.5 | 0.023 | 66.7/40.7 | 2.81(10x copy) |
| CYFRA | 48.8 | 74.2 | 0.016 | 65.0/50.0 | 1.3(ng/ml) |
| SCC | 58.9 | 58.3 | 0.032 | 20.7/87.5 | 1.5(ng/ml) |
| CEA | 40.1 | 74.4 | 0.376 | 65.0/39.1 | 2.8(ng/ml) |
| hTERT + EGFR mRNA | 82.8 | 77.7 | 0.001 | 89.8/73.7 | 5.38(10x copy) |
The sensitivity/specificity values are 71.8%/72.5% for hTERT mRNA, 60.8%/62.5% for EGFR mRNA, 48.8%/74.2% for CYFRA, 58.9%/58.3% for SCC, and 40.1%/74.4% for CEA. In the diagnostic assessment of sensitivity and specificity, hTERT mRNA (0.718/0.725) was identified as the most excellent tumor marker.PPV: positive predictive value, NPV: negative predictive value. Sensitivity, specificity, p value, and PPV/ NPV of hTERT + EGFR mRNA were calculated, based on the summation of each logarithmic cut-off values.