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. 2008 Apr 24;2:335–345. doi: 10.4137/cmo.s475

Figure 1. Protective mechanisms of HSP70s in stress-induced cell death.

Figure 1

HSP70s block the activation of several death factors to attenuate stress-induced cell death. iHSP70s inhibit caspase-8, JNK, p53, AIF and apoptosome formation to protect cell from apoptosis. Moreover, both iHSP70s and HSC70s stabilize lysosomal membrane and decrease cathepsin-dependent cell death. Besides, GRP78 diminishes caspase-dependent apoptosis by inhibiting Bax, BIK and caspase-7 activity. In addition, GRP75 traps p53 in the cytoplasm so that p53 cannot turn on the pro-apoptotic genes.