Table 1.
Classification of human heat shock protein 70 family.
| Protein | Gene locus symbol | Intracellular localization | Alternative name | PI/MW (kDa) | Inducibility | Reference |
|---|---|---|---|---|---|---|
| iHSP70s | ||||||
| HSP70-1 | HSPA1A | Nu/Cyto/Lyso | HSP72, Hsp70, Hsp70i, Hsp70-1a | 5.48/70.0 | Yes | 11, 12 |
| HSP70-2 | HSPA1B | Nu/Cyto/Lyso | HSP72, Hsp70, Hsp70-1b | 5.48/70.0 | Yes | 11, 12 |
| HSP70B′ | HSPA6 | Nu/Cyto | Hsp7070-6 | 5.76/70.4 | Yes | 13, 14 |
| HSC70s | ||||||
| HSC70 | HSPA8 | Nu/Cyto | Hsp70-8, HSP73 | 5.81/71.0 | No | 15 |
| HSP70-Hom | HSPA1L | Nu/Cyto | Hsp70-1l, Hsp70t | 5.48/70.0 | No | 16 |
| HSP70-3 | HSPA2 | Nu/Cyto | Hsp70-2, Hsp70-2b | 5.07/72.3 | No | 17 |
| GRP70s | ||||||
| GRP75 | HSPA9 | Mito | Mortalin, mtHsp75, Hsp70-9, PBP74 | 5.37/70.9 | Yes | 19, 20 |
| GRP78 | HSPA5 | ER | Bip, Hsp70-5 | 6.03/73.7 | Yes | 18 |
Abbreviations: Nu: nucleus; Cyto: cytoplasm; Mito: mitochondria; ER: endoplasmic reticulum; PBP: peptide binding protein; Bip: Immunoglobulin heavy chain-binding protein homolog.