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. 2011 Jul 27;31(30):11044–11054. doi: 10.1523/JNEUROSCI.2125-11.2011

Figure 2.

Figure 2.

rTMS treatments increase BDNF-induced association of the NMDARs and NMDAR synaptic anchoring protein PSD-95 with TrkB in prefrontal cortex. a, b, A representative blot (a) and normalized densitometric data (b) showing the Western analysis of the effect of 5 d rTMS on the levels of NMDAR subunits NR1 and NR2A as well as NMDAR synaptic anchoring protein PSD-95 associated with TrkB in response to exogenously added rhBDNF or endogenously release BDNF by K+-depolarization or 10 μm NMDA + 1 μm glycine in the anti-TrkB immunoprecipitates of prefrontal cortical slice lysates prepared from sham-treated or 5 d rTMS rats. The blots were stripped and reprobed with anti-TrkB to measure immunoprecipitation efficiency and loading. The data are means ± SEM of ratio of the optical intensity of the NR1, NR2A, and PSD-95 to the TrkB-145 kDa band derived from six independent determinations. *p < 0.01 compared to respective K–R-treated level in the same group. #p < 0.01 compared to respective response in the sham control group.