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. 2011 Aug 22;6(8):e23388. doi: 10.1371/journal.pone.0023388

Figure 5. Nanoparticle formulation decreases curcumin cytotoxicity.

Figure 5

SUPT1 cells (Panel A) or stimulated PBMCs (Panel B) were exposed to increasing concentrations (1, 5, 10, 25, 50 and 100 µM) of sol-curcumin, nano-curcumin, azidothymidine (AZT) or nano-apotransferrin (10, 50 and 100 µg) for 16 h, after which cell viability was determined by MTT assay. PBMCs were cultured in the presence of IL-2 (20 IU/ml). Cell viability in the absence of drug was defined as 0% cytotoxicity. Error bars indicate SD. ** P≤0.01, and ***, P≤0.001 compared to nano-curcumin. * indicates µg apotransferrin protein that carry equivalent molar concentration of the drug.