Table 1. Patient characteristics and clinicopathological variables and their prognostic value for disease-specific survival in 335 NSCLC patients (univariate analyses; log rank test).
Characteristic | Patients(n) | Patients(%) | Median survival(months) | 5-Year survival(%) | P |
Age | |||||
≤65 years | 156 | 47 | 83 | 55 | 0.34 |
>65 years | 179 | 53 | NR | 60 | |
Sex | |||||
Female | 82 | 25 | 190 | 63 | 0.20 |
Male | 253 | 75 | 83 | 56 | |
Smoking | |||||
Never | 15 | 5 | 19 | 43 | 0.23 |
Current | 215 | 64 | NR | 60 | |
Former | 105 | 31 | 71 | 54 | |
Performance status | |||||
PS 0 | 197 | 59 | NR | 63 | 0.013 |
PS 1 | 120 | 36 | 64 | 52 | |
PS 2 | 18 | 5 | 25 | 33 | |
Weight loss | |||||
<10% | 303 | 90 | 127 | 58 | 0.71 |
>10% | 32 | 10 | 98 | 57 | |
Histology | |||||
SCC | 191 | 57 | NR | 66 | 0.08 |
AC | 113 | 34 | 54 | 45 | |
LCC | 31 | 9 | 98 | 56 | |
Differentiation | |||||
Poor | 138 | 41 | 47 | 47 | <0.001 |
Moderate | 144 | 43 | 190 | 64 | |
Well | 53 | 16 | NR | 68 | |
Surgical procedure | |||||
Lobectomy+Wedge* | 243 | 73 | 190 | 61 | 0.004 |
Pneumonectomy | 92 | 27 | 37 | 47 | |
Pathological stage | |||||
I | 157 | 47 | 190 | 71 | <0.001 |
II | 136 | 40 | 61 | 51 | |
IIIa | 42 | 13 | 17 | 23 | |
Tumor status | <0.001 | ||||
1 | 85 | 25 | 190 | 74 | |
2 | 188 | 56 | 84 | 57 | |
3 | 62 | 19 | 25 | 36 | |
Nodal status | |||||
0 | 232 | 69 | 190 | 66 | <0.001 |
1 | 76 | 23 | 35 | 43 | |
2 | 27 | 8 | 18 | 18 | |
Surgical margins | |||||
Free | 307 | 92 | 190 | 58 | 0.29 |
Not free | 28 | 8 | 47 | 47 | |
Vascular infiltration | |||||
No | 284 | 85 | 190 | 58 | <0.001 |
Yes | 51 | 15 | 27 | 32 |
*Wedge, n = 10.
Abbreviations: NR = not reached; PS = Performance status; SCC = Squamous cell carcinoma, LCC = Large-cell carcinoma; AC = Adenocarcinoma (including bronchioloalveolar carcinoma).