Table 3. Results of Cox regression analyses (Backward stepwise model).
| Model 1(all significant variables entered) | Model 2(Clinicopathological and co-expression variable entered) | |||||
| Factor | Hazard Ratio | 95% CI | P | Hazard Ratio | 95% CI | P |
| Tumor status | <0.001 * | <0.001 * | ||||
| 1 | 1 | 1 | ||||
| 2 | 1.72 | 1.02–2.89 | 0.041 | 1.95 | 1.14–3.36 | 0.015 |
| 3 | 3.27 | 1.84–5.81 | <0.001 | 3.72 | 2.03–6.85 | <0.001 |
| Nodal status | <0.001 * | <0.001 * | ||||
| 0 | 1 | 1 | ||||
| 1 | 1.92 | 1.25–2.94 | 0.003 | 1.94 | 1.26–2.97 | 0.002 |
| 2 | 3.30 | 1.95–5.59 | <0.001 | 3.03 | 1.75–5.23 | <0.001 |
| Performance status | 0.001 * | 0.001 * | ||||
| ECOG 0 | 1 | 1 | ||||
| ECOG 1 | 2.02 | 1.37–2.98 | <0.001 | 2.03 | 1.37–2.99 | <0.001 |
| ECOG 2 | 2.16 | 0.95–4.91 | 0.065 | 2.10 | 0.92–4.77 | 0.077 |
| Vascular infiltration | 0.002 | 0.002 | ||||
| No | 1 | 1 | ||||
| Yes | 2.08 | 1.29–3.34 | 2.13 | 1.31–3.49 | ||
| Differentiation | 0.006 * | 0.006 * | ||||
| Well | 1 | 1 | ||||
| Moderate | 1.89 | 0.97–3.69 | 0.061 | 1.62 | 0.83–3.14 | 0.16 |
| Poor | 1.02 | 0.51–2.02 | 0.096 | 0.85 | 0.42–1.72 | 0.65 |
| PHD1 | 0.047 | |||||
| Low | 1 | |||||
| High | 1.45 | 1.01–2.10 | ||||
| PHD2 | 0.008 | |||||
| Low | 1 | |||||
| High | 2.03 | 1.20–3.42 | ||||
| Co-expression † | <0.001 * | |||||
| 0 | 1 | |||||
| 1 | 1.95 | 0.81–4.66 | 0.135 | |||
| 2 | 2.05 | 0.86–4.89 | 0.105 | |||
| 3 | 4.13 | 1.69–10.1 | 0.002 | |||
| 4 | 6.48 | 2.23–18.8 | 0.001 | |||
*Overall significance as a prognostic factor.
†
The co-expression variable, included all of the four oxygen sensors and was stratified by the total number of oxygen sensors with a high expression.
Grey boxes indicate variables not entered in the analysis.