Figure 1. Na⁺/H⁺ exchanger (NHE) is responsible for DCA-mediated Na⁺ influx.

A) Total cellular Na⁺ levels in JH-EsoAd1 cells (n = 6) after 60 minute incubation with various concentrations of DCA in the presence or absence of 20 uM EIPA. Values were calculated as nmol Na⁺/mg of protein (*p<0.01 compared to untreated cells). B) Graph shows intracellular pH (pH_i) measured in JH-EsoAd1 cells at 5, 20, 40 and 60 minute during indicated treatments. Data are expressed as change in pH_i from control (*p<0.01 compared to DCA alone or as indicated #p<0.01).