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. 2011 Aug 22;6(8):e23850. doi: 10.1371/journal.pone.0023850

Figure 1. In vivo effects of aconitase inhibition.

Figure 1

(A) Serum EPO levels in mice treated for 14 days with an infusion of saline (0.9%) or FA (4 mg/kg/day). Data represent mean ± SD; n = 9 for saline group and 10 for FA group; ‡ P<0.001. (B) Absolute reticulocyte counts in mice treated as in panel A. Data represent mean ± SD; n = 10 per group; ‡ P<0.001. (C) Erythroid maturation in marrows from mice who received a four-week infusion of FA (2 mg/kg/day) or saline (0.9%). Representative flow cytometry plots are shown. Boxes indicate erythroid developmental stages R1–R4, from top left (R1) to bottom right (R4). (D), (E) Summary of data from panel C displayed as cell percentages (D) or absolute cell numbers per femur (E) in regions R1–R4. Data is presented as mean ± SD; n = 4 per group; * P<0.05.