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. 2011 Aug 22;6(8):e23850. doi: 10.1371/journal.pone.0023850

Figure 2. Inhibition of aconitase impairs responsiveness to anemic challenge.

Figure 2

(A) RBC and (B) absolute reticulocyte counts in PHZ-challenged mice treated with either FA (4 mg/kg/day; n = 11) or saline (0.9%; n = 6). PHZ injections on days 0 and 1 consisted of 30 mg/kg/day for the FA group and 60 mg/kg/day for the saline group. Data represent mean ± SD. (C) RBC and (D) absolute reticulocyte counts in IRP1−/− and wild type (WT) mice. PHZ doses for both groups consisted of 60 mg/kg/day on days 0 and 1. Data represent mean ± SD; n = 8 per group.