TABLE 2.

Competition Binding Studies with PBR111 in Absence and Presence of 50 nM of PBR28

Binding class	Ki (nM) of…		Reduction (%) in specific signal after block with PBR28 (50 nM)
	PBR111	PBR111 after block with PBR28 (50 nM)
HABs	15.6 ± 3.7 (n = 5)	Not measurable	69.0 ± 4.6 (n = 4)
LABs	61.8 ± 10.7 (n = 5)	51.7 ± 12.2 (n = 4)	21.2 ± 4.8 (n = 4)
MABs	30.3 ± 4.1 (n = 4)	54.4 ± 5.3 (n = 4)	49.3 ± 2.9 (n = 4)
t test
HAB vs LAB	P < 0.003	NA	P < 0.0004
MAB vs LAB	P < 0.04	P < 0.84	P < 0.002
MAB vs HAB	P < 0.03	NA	P < 0.01

NA = not applicable.

Data are expressed as mean ± SEM.