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. 2011 Aug 25;7(8):e1002234. doi: 10.1371/journal.pgen.1002234

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Huang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) SOM cluster 3 genes nucleotide-binding oligomerization domain containing 1 (NOD1) and caspase 1 (CASP1) display strong temporal upregulation in symptomatic subjects. (B) SOM cluster 2 genes NOD2 and NLRP3 exhibit downregulation in Asx hosts and upregulation in symptomatic subjects. (C) SOM cluster 2 gene interleukin 1 beta (IL1B) shows symptomatic-specific upregulation versus Asx-specific downregulation over time. (D) SOM cluster 6 genes superoxide dismutase (SOD1) shows upregulation versus downregulation in Asx and Sx hosts, respectively. The expression values are plotted on a log base 2 scale and all genes are significantly differentially expressed between Asx and Sx (q-value0.0001; EDGE).

Inline graphic — (A) SOM cluster 3 genes nucleotide-binding oligomerization domain containing 1 (NOD1) and caspase 1 (CASP1) display strong temporal upregulation in symptomatic subjects. (B) SOM cluster 2 genes NOD2 and NLRP3 exhibit downregulation in Asx hosts and upregulation in symptomatic subjects. (C) SOM cluster 2 gene interleukin 1 beta (IL1B) shows symptomatic-specific upregulation versus Asx-specific downregulation over time. (D) SOM cluster 6 genes superoxide dismutase (SOD1) shows upregulation versus downregulation in Asx and Sx hosts, respectively. The expression values are plotted on a log base 2 scale and all genes are significantly differentially expressed between Asx and Sx (q-value0.0001; EDGE).