Abstract
Glasgow, Lowell A. (University of Rochester School of Medicine and Dentistry, Rochester, N.Y.). Leukocytes and interferon in the host response to viral infections. II. Enhanced interferon response of leukocytes from immune animals. J. Bacteriol. 91:2185–2191. 1966.—The production of interferon was studied under in vitro conditions in peritoneal leukocytes or macrophages from mice immunized with Chikungunya virus (CV). Cultures of leukocytes obtained from animals immune to CV produced 2- to 10-fold greater amounts of interferon when exposed to an inoculum of CV than similar cell preparations from nonimmune, control animals. The viral inhibitor produced in increased quantity by CV-immune leukocytes had the biological and biochemical properties of interferon. The enhanced interferon production was inhibited by actinomycin D. This response of immune leukocytes was specific, and was initiated only by CV; it was not observed in leukocytes from animals immunized against other viruses which were challenged with CV. The presence of neutralizing antibody could not be related to this response. The observed increase in interferon production was not dependent upon an enhanced virus uptake. The data are presented as a possible new dimension of the “immune response” and may suggest a mechanism for the phenomenon of “tissue immunity.”
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Selected References
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- BARON S. MECHANISM OF RECOVERY FROM VIRAL INFECTION. Adv Virus Res. 1963;10:39–64. doi: 10.1016/s0065-3527(08)60696-x. [DOI] [PubMed] [Google Scholar]
- GINDER D. R. Resistance to fibroma virus infection; the role of immune leukocytes and immune macrophages. J Exp Med. 1955 Jan 1;101(1):43–58. doi: 10.1084/jem.101.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GLASGOW L. A. INTERFERON: A REVIEW. J Pediatr. 1965 Jul;67:104–112. doi: 10.1016/s0022-3476(65)80311-0. [DOI] [PubMed] [Google Scholar]
- GLASGOW L. A. LEUKOCYTES AND INTERFERON IN THE HOST RESPONSE TO VIRAL INFECTIONS. I. MOUSE LEUKOCYTES AND LEUKOCYTE-PRODUCED INTERFERON IN VACCINIA VIRUS INFECTION IN VITRO. J Exp Med. 1965 Jun 1;121:1001–1018. doi: 10.1084/jem.121.6.1001. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HELLER E. ENHANCEMENT OF CHIKUNGUNYA VIRUS REPLICATION AND INHIBITION OF INTERFERON PRODUCTION BY ACTINOMYCIN D. Virology. 1963 Dec;21:652–656. doi: 10.1016/0042-6822(63)90239-3. [DOI] [PubMed] [Google Scholar]
- HO M. IDENTIFICATION AND "INDUCTION" OF INTERFERON. Bacteriol Rev. 1964 Dec;28:367–381. doi: 10.1128/br.28.4.367-381.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KEMPE C. H. Studies smallpox and complications of smallpox vaccination. Pediatrics. 1960 Aug;26:176–189. [PubMed] [Google Scholar]
- LEVY H. B., AXELROD D., BARON S. MESSENGER RNA FOR INTERFERON PRODUCTION. Proc Soc Exp Biol Med. 1965 Feb;118:384–385. doi: 10.3181/00379727-118-29850. [DOI] [PubMed] [Google Scholar]
- POLLIKOFF R., LIEBERMAN M., LEM N. E. ROLE OF INTERFERON AND PARTIAL IMMUNITY IN INFLUENZA VIRUS INFECTION OF MOUSE LUNG. Proc Soc Exp Biol Med. 1965 Jul;119:790–793. doi: 10.3181/00379727-119-30302. [DOI] [PubMed] [Google Scholar]
- ROBERTS J. A. GROWTH OF VIRULENT AND ATTENUATED ECTROMELIA VIRUS IN CULTURED MACROPHAGES FROM NORMAL AND ECTROMELIAIMMUNE MICE. J Immunol. 1964 Jun;92:837–842. [PubMed] [Google Scholar]
- STEINBERGER A., RIGHTS F. L. EFFECT OF IMMUNIZATION ON TISSUE SUSCEPTIBILITY TO VACCINIA VIRUS IN VITRO. Virology. 1963 Nov;21:402–410. doi: 10.1016/0042-6822(63)90202-2. [DOI] [PubMed] [Google Scholar]
- WAGNER R. R. INHIBITION OF INTERFERON BIOSYNTHESIS BY ACTINOMYCIN D. Nature. 1964 Oct 3;204:49–51. doi: 10.1038/204049a0. [DOI] [PubMed] [Google Scholar]
- Youngner J. S., Stinebring W. R. Interferon appearance stimulated by endotoxin, bacteria, or viruses in mice pre-treated with Escherichia coli endotoxin or infected with Mycobacterium tuberculosis. Nature. 1965 Oct 30;208(5009):456–458. doi: 10.1038/208456a0. [DOI] [PubMed] [Google Scholar]