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. 2011 Jul 18;12:289. doi: 10.1186/1471-2105-12-289

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Copyright © 2011 Gallone et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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'DNA Replication' sub-network in NET_DS_DMEL_known and NET_DS_DMEL_union. A: Data extracted from NET_DS_DMEL_known as follows: 1. select 10 core genes annotated with DNA replication GO biological process. 2. select all their nearest neighbours. B: NET_DNArep. Obtained as before, but data are extracted from from NET_DS_DMEL_union. B-D: Using the IPX to refine the putative sub-network in B. We set (C) and (D). IPX score values are mapped to edge thickness in B-D. Figure 7D shows the sub-network backbone possessing the highest confidence according to the algorithm. Black nodes are genes annotated with the DNA Replication GO biological process. Black connections are experimental PPI data from EBI Intact while red connections are putative predictions taken from NET_DS_DMEL_putative. Nodes are described in key. A high-resolution version of B is presented in Additional File 6: 'NET_DNARep'.

Inline graphic — 'DNA Replication' sub-network in NET_DS_DMEL_known and NET_DS_DMEL_union. A: Data extracted from NET_DS_DMEL_known as follows: 1. select 10 core genes annotated with DNA replication GO biological process. 2. select all their nearest neighbours. B: NET_DNArep. Obtained as before, but data are extracted from from NET_DS_DMEL_union. B-D: Using the IPX to refine the putative sub-network in B. We set (C) and (D). IPX score values are mapped to edge thickness in B-D. Figure 7D shows the sub-network backbone possessing the highest confidence according to the algorithm. Black nodes are genes annotated with the DNA Replication GO biological process. Black connections are experimental PPI data from EBI Intact while red connections are putative predictions taken from NET_DS_DMEL_putative. Nodes are described in key. A high-resolution version of B is presented in Additional File 6: 'NET_DNARep'.