Table 2.
Quantitative trait analyses of the effect of rs7072268 of HK1 among 5,604 non-diabetic individuals from the Inter99 study population
| Trait | CC | CT | TT | Padd | Badd (CI) |
|---|---|---|---|---|---|
| N (men/women) | 1545 (765/780) | 2757 (1347/1410) | 1302 (644/658) | ||
| Age (years) | 46.1 ± 8.0 | 45.8 ± 7.9 | 45.9 ± 7.7 | ||
| Body composition | |||||
| BMI (kg/m2) | 25.9 ± 4.4 | 26.1 ± 4.4 | 26.0 ± 4.3 | 0.5 | 0.06 (-0.10; 0.22) |
| Waist-to-hip ratio | 0.85 ± 0.08 | 0.85 ± 0.09 | 0.85 ± 0.09 | 0.2 | 0.001 (-0.001; 0.003) |
| Waist (cm) | 86.7 ± 12.9 | 86.1 ± 12.8 | 85.8 ± 12.8 | 0.9 | -0.12 (-0.20; 0.18) |
| Lipids | |||||
| Triglycerides* (mmol/l) | 1.0 (0.8; 1.4) | 1.1 (0.8; 1.5) | 1.1 (0.8; 1.5) | 0.03 | 2.0 (0.2;3.8) |
| Cholesterol (mmol/l) | 5.5 ± 1.0 | 5.5 ± 1.1 | 5.6 ± 1.1 | 0.001 | 0.06 (0.03; 1.0) |
| HDL cholesterol (mmol/l) | 1.4 ± 0.4 | 1.4 ± 0.4 | 1.4 ± 0.4 | 0.7 | 0.003 (-0.010; 0.016) |
| LDL cholesterol (mmol/l) | 3.5 ± 1.0 | 3.5 ± 0.9 | 3.6 ± 1.0 | 0.1 | 0.04 (-0.01; 0.09) |
| VLDL cholesterol (mmol/l) | 0.6 ± 0.3 | 0.6 ± 0.3 | 0.6 ± 0.3 | 0.1 | 0.01 (-0.004; 0.03) |
| Serum Insulin | |||||
| Fasting serum Insulin * (pmol/l) |
33.0 (23.0; 47.0) | 34.0 (24.0; 51.0) | 33.0 (23.0; 51.0) | 0.2 | 1.2 (-0.7; 2.7) |
| Serum insulin 30 min * (pmol/l) |
242 (173; 355) | 250 (179; 354) | 244 (179; 359) | 0.6 | 0.5 (-1.4; 2.4) |
| Serum insulin 120 min * (pmol/l) | 151 (94.3; 242) | 155 (96.0; 249) | 148 (91.0; 248) | 0.9 | 0.1 (-2.6; 2.9) |
| AUC insulin* (pmol/l * min) |
22460 (16200; 32620) | 23490 (16950; 32770) | 22820 (16770; 32910) | 0.2 | 0.8 (-1.1; 2.6) |
| Plasma glucose | |||||
| Fasting Plasma glucose (mmol/l) | 5.4 ± 0.5 | 5.5 ± 0.5 | 5.5 ± 0.5 | 0.2 | 0.01 (-0.004; 0.03) |
| Plasma glucose 30 min (mmol/l) | 8.5 ± 1.67 | 8.6 ± 1.7 | 8.6 ± 1.7 | 0.1 | 0.05 (-0.004; 0.1) |
| Plasma glucose 120 min (mmol/l) | 5.9 ± 1.56 | 6.0 ± 1.5 | 6.0 ± 1.5 | 0.1 | 0.04 (-0.02; 0.09) |
| AUC glucose (mmol/l* min) |
856 ± 143 | 865 ± 145 | 866 ± 144 | 0.045 | 5.0 (0.1; 10.0) |
| Indices of insulin sensitivity | |||||
| HOMA-IR* | 7.8 (5.4; 11.6) | 8.3 (5.7; 12.6) | 7.9 (5.4; 12.8) | 0.2 | 1.3 (-0.6; 3.3) |
| DI* | 204 (140; 291) | 194 (130; 279) | 197 (129; 285) | 0.3 | -1.2 (-3.3; 0.9) |
| ISI* | 8.3 (5.6; 9.5) | 7.8 (5.3; 11.1) | 8.0 (5.2; 11.6) | 0.1 | -1.4 (-3.2-0.4) |
| Indices of acute insulin response | |||||
| Insulinolinogenic Index* | 24.9 (17.3; 37.1) | 25.1 (17.0; 37.3) | 24.7 (17.4; 36.1) | 0.8 | 0.4 (-1.8; 2.5) |
| Glycated haemoglobin levels | |||||
| Hba1c* (%) | 5.8 (5.5; 6.0) | 5.8 (5.5; 6.1) | 5.8 (5.6; 6.1) | 3e-07 | 0.6 (0.4; 0.9) |
Data are presented as mean ± SD and as effect sizes (95% CI) for traits following a normal distribution. Remaining traits are presented as median (inter-quartile range) and their effect sizes are presented as increase/decrease in percentage. Multiple regression analysis was used to test for difference between genotype groups. P-values are corrected for sex and age. * = log transformation.