Figure 9. ORF61 SIMs are not required for VZV replication in non-proliferating cells in vitro.
(A) Confocal microscopy of mock-, pOka-, or pOka-mSIM-N&C-infected skin xenografts that were stained for the proliferation marker Ki67 (green) and nuclei (blue). Scale bars: 100 µm. (B) Confocal microscopy of normal and serum-starved HELFs that were stained for the proliferation marker Ki67 (green) and nuclei (blue). Scale bars: 100 µm. (C) Replication of pOka and pOka-mSIM-N&C in normal and serum-starved HELFs. Each point represents mean±SEM of virus titers from three replicates for each virus under normal and serum-starved conditions.