Table 2. Haplotype associations of SNPs belonging to the six LD blocks of LMX1B, in 252 trios.

Block	Haplotype*	Frequency	T(%)	Individual p-	Permutation p-	Block p-
				value†	value‡	value
Block 1 (SNPs 01–06)	GGTATG	0.355	51.67	0.6291	1
	GACATA	0.25	48.81	0.7487	1
	GACACG	0.244	45.71	0.2568	0.994
	AGCGTG	0.073	66.13	0.0079	0.114
	GACATG	0.052	51.42	0.8461	1
	GGTACG	0.014	30.77	0.1658	0.97	0.096
Block 2 (SNPs 08–09)	CC	0.406	50.23	0.9432	1
	TC	0.353	54.03	0.2242	0.987
	TA	0.239	44.23	0.1255	0.892	0.258
Block 3 (SNPs 10–11)	CG	0.525	48.4	0.6123	1
	TA	0.345	52.71	0.4094	1
	CA	0.126	48.79	0.8046	1	0.731
Block 4 (SNPs 12–16)	GGCGA	0.379	53.41	0.3114	0.998
	GGCGG	0.209	45.31	0.2362	0.991
	GACCG	0.201	48.99	0.8072	1
	GGTCG	0.119	55.41	0.2624	0.994
	TGTCG	0.071	48.81	0.8455	1	0.595
Block 5 (SNPs 18–19)	AA	0.58	52.42	0.4476	1
	GA	0.304	47.25	0.1587	0.966
	GG	0.112	53.61	0.4772	1	0.354
Block 6 (SNPs 20–22)	GGC	0.35	55.39	0.111	0.868
	GAC	0.332	48.19	0.59	1
	GGT	0.21	47.63	0.5365	1
	TGC	0.107	46.45	0.4947	1	0.512

T: Transmitted / (Transmitted + Untransmitted).

‡10,000 permutations.

*All possible combinations of haplotypes with frequency >0.01 †Significant p-values (<0.05) are indicated in bold italics.