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. 2011 Aug 25;6(8):e23709. doi: 10.1371/journal.pone.0023709

Figure 2. Rapid response of gene expression after resumed feeding in liver of Clock mutant mice.

Figure 2

(A) Experimental design. Clock mutant mice were bred under constant light (LL) for 3 weeks, fasted for 24 h and then fed for 8 h. (B) Representative actogram from mice under 12-h light-dark (LD) cycle for 2 weeks that were switched to LL. (C–F) Expression profiles of mRNAs for clock genes (C), genes related to glucose metabolism (D–E), and fatty acid synthesis (F). Gray bars in both panels, duration of resumed feeding. Data are shown as means ± SEM (n = 5 for 25 h, n = 4 for 12, 18, 24 and 26 h, and n = 3 for 6, 28, and 32 h; *p<0.05, **p<0.01; 24 h vs. 25–32 h; Dunnett's test).