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. 2011 Aug 25;6(8):e23795. doi: 10.1371/journal.pone.0023795

Table 1. Mean error of 6- and 4-variable reduced models compared with original model.

Species Name Mean Error (%)
6-Variable Model 4-Variable Model
Ligand 0.4 0.4
Gs 0.1 0.1
β1ARtot 0.2 0.2
β1ARd 0.9 0.9
β1ARp 0.5 0.5
Gsαgtptot 0.3 0.3
Gsαgtp 1.7 1.7
AC 0.1 0.1
cAMPtot 1 1
cAMPfree 1.7 1.6
PKA1 2.6 2.6
PKA2 1.3 1.3
PLBp 3.8 11.5
Inhib1ptot 2.7 2.7
Inhib1p 3.1 3.1
PP1 0.2 0.2
LCCap 2.2 2.2
LCCbp 2 2
TnIp 3.6 24.5
Mean 1.5 3

Errors for 19 of the original 25 state variables are shown. Not shown are Forskolin and IBMX (set to 0 µM for most conditions), PDE, β1ARfree, Gsαgdp, and Gsβγ (which were removed from or no longer necessary for the models).