Table 1. Mean error of 6- and 4-variable reduced models compared with original model.
Species Name | Mean Error (%) | |
6-Variable Model | 4-Variable Model | |
Ligand | 0.4 | 0.4 |
Gs | 0.1 | 0.1 |
β1ARtot | 0.2 | 0.2 |
β1ARd | 0.9 | 0.9 |
β1ARp | 0.5 | 0.5 |
Gsαgtptot | 0.3 | 0.3 |
Gsαgtp | 1.7 | 1.7 |
AC | 0.1 | 0.1 |
cAMPtot | 1 | 1 |
cAMPfree | 1.7 | 1.6 |
PKA1 | 2.6 | 2.6 |
PKA2 | 1.3 | 1.3 |
PLBp | 3.8 | 11.5 |
Inhib1ptot | 2.7 | 2.7 |
Inhib1p | 3.1 | 3.1 |
PP1 | 0.2 | 0.2 |
LCCap | 2.2 | 2.2 |
LCCbp | 2 | 2 |
TnIp | 3.6 | 24.5 |
Mean | 1.5 | 3 |
Errors for 19 of the original 25 state variables are shown. Not shown are Forskolin and IBMX (set to 0 µM for most conditions), PDE, β1ARfree, Gsαgdp, and Gsβγ (which were removed from or no longer necessary for the models).