Table 2.
Parameters | Orlistat (n = 40) | Metformin (n = 40) | |||||||
---|---|---|---|---|---|---|---|---|---|
Baseline | 3 months | Changes (%) | P-value* | Baseline | 3 months | Changes (%) | P-value* | P-value** Metformin vs. Orlistat | |
BMI (kg/m2) | 34.88 ± 4.90 | 33.24 ± 4. 19 | −4.48 ± .47 | <001 | 32.49 ± 3.06 | 31.03 ± 3.43 | −4.55 ± .70 | <001 | n.s |
Waist (cm) | 113.25 ± 11.96 | 110.85 ± 11.86 | −3.88 ± .40 | <001 | 104.15 ± 9.22 | 100.80 ± 9.83 | −5.04 ± .67 | <001 | n.s |
Weight (kg) | 87.05 ± 13.62 | 83.47 ± 11.80 | −3.88 ± .40 | <001 | 79.80 ± 9.63 | 75.85 ± 10.21 | −5.04 ± .67 | <001 | n.s |
LH (mIU/ml) | 7.92 ± 4.42 | 7.02 ± 5.90 | −3.9 ± 10.32 | .056 | 6.58 ± 4.81 | 5.25 ± 3.77 | −5.7 ± 8.58 | .008 | n.s |
Testosterone (ng/ml) | 0.80 ± 0.23 | 0.63 ± 0.22 | −19.37 ± 3.52 | <001 | 0.78 ± 0. 44 | 0.66 ± 0.34 | −17.30 ± 5.30 | 0.053 | n.s |
Cholesterol (mg/dl) | 215.05 ± 38.42 | 194.30 ± 47. 04 | −9.39 ± 2.43 | .001 | 169.80 ± 27.97 | 165.85 ± 24.36 | −1.54 ± 1.76 | . 30 | .023 |
TG (mg/dl) | 194.10 ± 70.76 | 155.85 ± 65.75 | −15.26 ± 4.93 | .001 | 133.95 ± 41.30 | 108.50 ± 52.51 | −19.97 ± 3.40 | <.001 | n.s |
Data are presented as mean ± SEM. All serum results are obtained from fasting variables
BMI, body mass index; LH, luteinizing hormone; TG, triglyceride
P* for paired t-test and Wilcoxon signed rank test; p** for student t-test and Mann-whitney U test