Table 2.

Subject characteristics at the baseline and after 3-month treated period

Parameters	Orlistat (n = 40)				Metformin (n = 40)
	Baseline	3 months	Changes (%)	P-value*	Baseline	3 months	Changes (%)	P-value*	P-value** Metformin vs. Orlistat
BMI (kg/m2)	34.88 ± 4.90	33.24 ± 4. 19	−4.48 ± .47	<001	32.49 ± 3.06	31.03 ± 3.43	−4.55 ± .70	<001	n.s
Waist (cm)	113.25 ± 11.96	110.85 ± 11.86	−3.88 ± .40	<001	104.15 ± 9.22	100.80 ± 9.83	−5.04 ± .67	<001	n.s
Weight (kg)	87.05 ± 13.62	83.47 ± 11.80	−3.88 ± .40	<001	79.80 ± 9.63	75.85 ± 10.21	−5.04 ± .67	<001	n.s
LH (mIU/ml)	7.92 ± 4.42	7.02 ± 5.90	−3.9 ± 10.32	.056	6.58 ± 4.81	5.25 ± 3.77	−5.7 ± 8.58	.008	n.s
Testosterone (ng/ml)	0.80 ± 0.23	0.63 ± 0.22	−19.37 ± 3.52	<001	0.78 ± 0. 44	0.66 ± 0.34	−17.30 ± 5.30	0.053	n.s
Cholesterol (mg/dl)	215.05 ± 38.42	194.30 ± 47. 04	−9.39 ± 2.43	.001	169.80 ± 27.97	165.85 ± 24.36	−1.54 ± 1.76	. 30	.023
TG (mg/dl)	194.10 ± 70.76	155.85 ± 65.75	−15.26 ± 4.93	.001	133.95 ± 41.30	108.50 ± 52.51	−19.97 ± 3.40	<.001	n.s

Data are presented as mean ± SEM. All serum results are obtained from fasting variables

BMI, body mass index; LH, luteinizing hormone; TG, triglyceride

P* for paired t-test and Wilcoxon signed rank test; p** for student t-test and Mann-whitney U test