Table 2.
Odds-Ratios [95% Confidence Interval] of the different APOE genotypes (using APOE 33 genotype as reference).
| Age-group | Sample Size (Cases/Controls) | APOE 44 | APOE 34 | APOE 24 | APOE 22+23 |
|---|---|---|---|---|---|
| Less than 60 | 593/610 | 5.60 [3.17;9.89] | 2.09 [1.61;2.71] | 1.29 [0.61;2.71] | 0.43 [0.24;0.77] |
| 60 to 70 | 1511/2614 | 35.07 [23.8;51.68] | 4.18 [3.59;4.88] | 2.2 [1.32;3.68] | 0.59 [0.43;0.82] |
| 70 to 80 | 3244/5175 | 15.75 [11.93;20.8] | 4.54 [4.09;5.05] | 2.79 [2.05;3.8] | 0.51 [0.41;0.63] |
| More than 80 | 2183/1733 | 7.87 [4.28;14.46] | 3.16 [2.68;3.72] | 3.77 [2.28;6.23] | 0.59 [0.47;0.74] |
|
| |||||
| All | 7531/10132 | 14.49 [11.91; 17.64] | 3.63 [3.37; 3.90] | 2.64 [2.13; 3.27] | 0.56 [0.49; 0.64] |
| p-valuea | 1.05×10−7 | 3.40×10−8 | 0.11 | 0.64 | |
a
P-value of the Woolf test of homogeneity of OR between the different age categories.