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. Author manuscript; available in PMC: 2012 Sep 15.
Published in final edited form as: Biol Psychiatry. 2011 May 20;70(6):561–567. doi: 10.1016/j.biopsych.2011.04.003

Table 2.

Regions with significant volume differences in group comparisons.

Contrast Location of region Cluster Volume (cc) Corrected p-value Effect* (%)
Relapsers+Abstainers vs. LD Right temporal (including insula), frontal lobe 11.7 0.001 −8.5
Abstainers vs. LD (1) Left amygdala, head of hippocampus, entorhinal cortex, thalamus, adjacent WM 11.7 <0.001 −9.5
(2) Right thalamus, right colliculi, adjacent WM 4.9 0.016 −11.4
(3) Left orbitofrontal 2.1 0.035 +10.1
Relapsers vs. LD (4) Right middle temporal (including insula) 15.7 <0.001 −9.1
(5) Right occipital 6.0 0.031 −12.6
(6) Left superior corona radiata 12.5 0.043 −10.3
Relapsers vs. Abstainers (7) Left lateral orbitofrontal 8.1 <0.001 −10.8
(8) Left fronto-temporo-parietal 9.9 0.014 −14.4
(9) Right lateral orbitofrontal 3.8 0.033 −8.0
(10) Left amygdala, head of hippocampus, entorhinal cortex 3.6 0.115 +9.1
*

negative numbers indicate % tissue loss in alcohol groups vs. LD or in Relapsers vs. Abstainers Numbers in parenthesis identify locations in Figure 1.