Skip to main content
. 2009 Apr 29;29(17):5525–5535. doi: 10.1523/JNEUROSCI.5469-08.2009

Figure 2.

Figure 2.

Nmnat enzymatic activity is critical for axonal protection. A, Representative images of axons of DRG neurons infected with lentivirus expressing EGFP, Nmnat1, Nmnat1(H24A), or Nmnat1(W170A) are shown. Axons from Nmnat1-expressing DRG neurons were protected after axotomy, whereas axons from Nmnat1(H24A)- or Nmnat1(W170A)-expressing neurons degenerated similarly to those expressing EGFP. B, The quantification of axonal degeneration in DRG neurons expressing EGFP, Nmnat1, Nmnat1(H24A), or Nmnat1(W170A). Twelve fields were evaluated for each condition, and each experiment was repeated three times. The degeneration index value ± SD at 24, 48, and 72 h is displayed. Only Nmnat1 shows significant axonal protection (p < 0.001, n = 3).