Table 2. IC50 Values of the Isolated Lignan Derivatives (1–11) in NF-κB, COX-1, COX-2, 5-LO, mPGES-1, and DPPH Assays (values in μM).
| compound | inhibition of NF-κB | inhibition of COX 1 | inhibition of COX 2 | inhibition of mPGES-1 | inhibition of 5-LO | radical scavenging activity |
|---|---|---|---|---|---|---|
| parthenolide | 1.4 ± 0.3 | |||||
| indomethacin | 2.1 ± 1.3 | |||||
| NS-398 | 2.1 ± 1.1 | |||||
| MK-886 | 2.1 ± 0.4 | |||||
| zileuton | 6.3 ± 1.4 | |||||
| ascorbic acid | 24.2 ± 5.1 | |||||
| 1 | 13.1 ± 3.7 | >50 | >50 | >50 | 41.4 ± 7.5 | 37.7 ± 4.4 |
| 2 | 11.6 ± 1.8 | >50 | >50 | >50 | >50 | |
| 3 | >20 | >50 | >50 | >50 | >50 | |
| 4 | 14.2 ± 2.3 | >50 | >50 | 39.5 ± 4.9 | >50 | |
| 5 | 5.9 ± 1.2 | >50 | >50 | 42.0 ± 7.4 | 27.2 ± 8.8 | 42.3 ± 2.6 |
| 6 | 3.4 ± 1.1 | 3.8 ± 0.8 | 7.1 ± 1.0 | 7.4 ± 1.7 | >50 | 22.1 ± 5.2 |
| 7 | >20 | >50 | >50 | 19.5 ± 0.8 | 18.4 ± 3.4 | |
| 8 | 1.4 ± 0.3 | 18.3 ± 4.3 | 2.0 ± 0.6 | 5.3 ± 1.3 | >50 | |
| 9 | >20 | 2.7 ± 2.1 | 7.6 ± 1.8 | 13.5 ± 2.8 | >50 | 36.3 ± 6.7 |
| 10 | 14.7 ± 3.2 | >50 | >50 | 13.0 ± 2.2 | >50 | 24.2 ± 5.8 |
| 11 | 6.4 ± 1.1 | 3.0 ± 0.7 | 1.7 ± 0.4 | 11.0 ± 1.6 | >50 |