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B. mallei bacterial burden in treated and untreated BABLB/c mice. CSM001 was i.n. inoculated into BALB/c mice as indicated previously for the bioluminescent imaging. At each time point, untreated (closed symbols) or treated (open symbols) animals with 20 mg/kg/day of levofloxacin were sacrificed and the lungs (A) and spleen (B) were harvested at 24 h (squares), 48 h (circles), 72 h (diamonds) and plated for CFU determination.
