Fig. 3.
Analysis of cell cycle checkpoint proteins in wild-type and β2SP+/− mouse livers following partial hepatectomy. (A) Western blot analysis and densitometric analysis (B) of p53 and p21 expression demonstrated significant elevation in mutant mice beginning at 24 hours post-PHx. Mutant mice also demonstrated increased pCdk1 (Thr14) expression and delayed peak in pSTAT3 (Tyr705), consistent with growth arrest. (* P<0.05)