Table 3.
Multivariate Cox regression analysis controlling for PSA, Gleason Grade, pathologic stage, surgical margin, age, and race in patients NED after RP. All p values from Wald test.
| Variable | Time from RP
|
Time from BM
|
||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p | Hazard ratio (95% CI) | p | |
| DTC | 6.87 (1.03–45.87) | 0.047 | 4.20 (0.79–22.39) | 0.09 |
| PSA | 1.00 (0.86–1.16) | 0.97 | 1.04 (0.91–1.81) | 0.91 |
| Grade | ||||
| 4–6 | 1.0 (referent) | 1.0 (referent) | ||
| 7 | 4.7 (1.20–18.49) | 0.03 | 4.14 (1.15–14.97) | 0.03 |
| 8–10 | 8.23 (0.58–116.20) | 0.12 | 5.45 (0.39–76.17) | 0.21 |
| Stage | ||||
| T2 | 1.0 (referent) | 1.0 (referent) | ||
| T3-4 or N+ | 2.17 (0.62–7.63) | 0.23 | 2.26 (0.64–7.95) | 0.2 |
| Margin (+) | 1.6 (0.43–6.0) | 0.49 | 1.89 (0.55–6.52) | 0.31 |
| Age | ||||
| 40–50 | 1.0 (referent) | 1.0 (referent) | ||
| 51–60 | 1.08 (0.21–5.64) | 0.93 | 0.99 (0.18–5.31) | 0.99 |
| >60 | 1.25 (0.20–7.65) | 0.81 | 0.80 (0.13–5.06) | 0.82 |
| Race | 2.55 (0.21–31.25) | 0.47 | 0.74 (0.07–7.01) | 0.79 |
Abbreviations: DTC, disseminated tumor cells; PSA, prostate specific antigen