Effect of restraint stress and selective CRF2 receptor blockade on time spent grooming (in seconds). Values shown are means ± SEMs. For all groups, n = 8–9. Grooming was assessed for 15 minutes, beginning immediately after restraint termination on days 1, 3, and 5. Restrained rats spent more time grooming than control rats (*p < 0.001 vs. No Restraint, main effect). Administration of ASV-30 prior to restraint did not alter the restraint-induced increase in grooming behavior.