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. 2011 Jul 6;118(8):2138–2149. doi: 10.1182/blood-2011-01-328781

Figure 4.

Figure 4

TCR avidity determines the efficacy of HIV suppression by CD8+ T cells. (A) HLA-B*2705+ CD4+ T cells infected with wt (HIVNL4-3) or ΔNef (HIVNL4-3ΔNef) viruses were assayed for HLA-B*27 expression by flow cytometry. Surface expression of HLA-B*27 is shown for infected p24+ cells (gray) and uninfected p24− cells (black). (B) Representative flow cytometry plots showing p24 expression in CD4+ T cells infected with titrated amounts of wt or ΔNef viruses after 3 days of coculture with high- or low-avidity CD8+ T-cell clones. Percentages of p24+ cells and E:T ratios are indicated. (C) Fold decrease in the percentage of p24+ CD4+ T cells infected with titrated amounts of wt or ΔNef viruses after 3 days of coculture with higher (n = 4) or lower (n = 4) avidity CD8+ T-cell clones at E:T ratios of 1:1. The Wilcoxon signed-rank test was used to compare suppression of wt versus ΔNef viruses. **P < .01.