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. 2011 Jul 8;286(35):30926–30936. doi: 10.1074/jbc.M111.264325

FIGURE 6.

FIGURE 6.

Interleukin-6 induces an anti-inflammatory macrophage phenotype. Human Ctrl and ABCA1 KD THP-1 macrophages were cholesterol-loaded or not with acLDL and incubated in the absence or in the presence of IL-6 (50 ng/ml) for 24 h. The secretion of IL-4 (A), IL-10 (B), IL-1α (C), IL-1β (D), and TNFα (E) cytokines in the culture media was quantified on a semiautomated Biochip Array analyzer (Randox). *, p < 0.05; **, p < 0.005; ***, p < 0.0005 versus respective cells nonstimulated by IL-6; #, p < 0.05; ##, p < 0.005, ###, p < 0.0005 versus noncholesterol-loaded respective cells; †, p < 0.05; ††, p < 0.005; †††, p < 0.005 versus respective Ctrl cells. Values are the means ± S.E. of three independent experiments performed in triplicate.